WVE Wave Life Sciences Ltd

$WVE Trading near net cash (~$2.20) means Wall St is assigning $0 value to the entire RNA platform. Pure nonsense given $19 offering & RA Cap buying at $6. Key catalysts ahead: 🔹 WVE-006 (AATD): Patient MAD proof-of-concept data 🔹 WVE-007 (Obesity): Ph 1/2 clinical readout 🔹 WVE-N531 (DMD): Exon skipping follow-up 🔹 WVE-003 (HD): Post-dose selection advances 🔹 WVE-008 (Stargardt): RNA editing advances in ABCA4 Nothing left to lose at these levels.

$WVE Wave Life Sciences got FDA alignment on the registrational pathway for WVE-006, its RNA-editing candidate for alpha-1 antitrypsin deficiency (company release, Oct 1). The structure is the story: a single two-year registrational trial, with a one-year interim analysis that could support accelerated approval based on AATD biomarkers. No separate confirmatory trial. Why that matters: today's standard of care is IV augmentation therapy, which can leave patients with depleted AAT levels during lung exacerbations and does nothing for the liver risk. WVE-006 is a subcutaneous RNA edit designed to produce healthy M-AAT while reducing the mutant Z-AAT aggregates trapped in the liver. Next hard read: data from the 600 mg monthly multidose cohort of the RestorAATion-2 trial, expected in Q4. The tape barely noticed. Up about 5% Thursday on the news, half of it given back Friday. Closed at 3.78, around 82% below the 52-week high.

$WVE This stock reminds of VTYX. Owned a 20K stake at around $2 per share. Large institutional ownership and Sanofi had an equity stake. Stock was viciously attacked almost everyday by shorts all the way down to a dollar. Sold out at 1.50 and took the loss when no insiders bought at that ridiculous price. Stock finally bottomed and began a slow rise at first then found its legs. I did not rebuy even when it bottomed out,but should have. It was eventually bought by Lilly for $14 a share. Lesson learned that in these small bios where news is often sparse between trial news,the shorts take advantage of this and anyone owning it takes the mental abuse of the constant downward trend till they can no longer stand it and sell out. Been there and know that pain.

$WVE Fresh aggressive PT at $42🚀 Yesterday shorts took advantage of XBI sell-off with 56% short but the clock is ticking💥 they will get burned🔥

$WVE still feel it's trading low. It should be 15$ and above after 2 good news GSK partnership going strong and FDA giving approval to fast track WVE 006

$WVE The market cap path from $765M ($3.9) to $3B+ (+$15) 💥🚀 Beam is valued $2.5B near at 52 wk low, and Viking is valued $3.88B also near 52 week low! So WVE target is $3B by EOY 💎🙌🏼

$WVE And i thought I naild the low at 5.02 after the 07 update, HA! Especially afte RA came out and said it was way overdone. Well, RA, what you got to say now?

$WVE SUPER Bullish..Here is why. To answer why is stock initially down..HIGHER interests daily is poison for ALL small stocks w/o earnings..and spared very few (usually they are selling ETFs and not really picking on any single stocks), BUT after the current news involving Glaxo and then FDA news today, I am extemely bullish. Any other time it would be up to $7-9 easy. I hate analysts, but even they have recently brought down 12 month target down to over $18..I helped start Amgen years ago, and feel that is is now a very low risk/high return stock. DR Kalerman

$WVE The chart is totally broken, and shorts are in control but not for so long. The Market cap is $780M as of today, as if they have have 1 drug and no assets. The FDA feedback is imminent (next 2-3 week) on a potential accelerated node of WVE006, which will de risk their RNA platform and force the re rate to $10 a share ($2B market cap). Q4 is a biggest catalyst with WVE007 readout that can trigger a buyout to take us to a 52 week high of $21🚀💎🙌🏼

$WVE You’re killing me smalls! Yahoo Finance was right, flush below $4 before the turnaround

$WVE It’s devastating. Hope this gives us some green eventually. Chart is total sh*t. The real issue is how it crushes your confidence. Reminds me of holding SMMT at 1.8—kept buying every dip because insider buying made me conviction-heavy. But WVE is just a straight falling knife... Anyway, sorry for the rant.

$WVE high conviction is adding when the price action stays broken for months. When the broader market keeps making fresh highs and your top position just grinds lower week after week, that extended price action causes serious self doubt. It makes you question your judgment, your thesis, and your patience. It is easy to feel confident when the chart validates you. It is a completely different discipline to stay grounded when a stock acts like it is heading for liquidation while the fundamental story remains intact. Earlier in my career, prolonged price suppression would get inside my head and force unforced errors. Over time, you learn that the market isn't here to give you daily validation. The best asymmetric setups usually feel terrible right up until they don't. True conviction means looking past extended noise, and letting the process play out without needing the chart to tell you you're right every morning, especially in small cap biotech

$WVE Sept and Oct are not good for bios. Many have been down 20, 30 or 40%. Nothing has changed, same for WVE, or it has been positive since FDA allows the use of biomarkers. Considering cash and the pipeline, sp will make a turn. Hold on tight until >10

$WVE Macro headwinds and rapidly rising interest rates are crushing small-cap biotech. Still long; however, feeling like frogger!

$WVE down 28% in the last month I guess the only question now is how much will we be down monday - shorts appear to be making a killing right now.

$WVE My portfolio is down so much that I'm officially immune to the pain. Send it lower, I feel nothing 🚀📉😴

$WVE starting to see a little action at least, we just got a 400k print and a few around 100k for about a million shares traded in the last 25 minutes. IV also spiked this morning to a new high and is picking back up into close near previous highs. It feels so artificial but it doesn’t make it any easier to sit through

$WVE M - Nasdaq Real Time Price • USD Wave Life Sciences, Inc. (WVE) 3.1850 -0.0950 (-2.90%) As of 10:39:46 AM EDT. Market Open. how low are shorts going to take this 2? This is unreal

$WVE I remember selling this in the mid 5's after that horrendous chat they had where they said they don't know if any of their drug candidates were any good and can't promise anything. That was the wildest thing I've ever heard. Of course, there were still people defending it then...

$WVE someone blocked me for one of my posts. Hope the sheep traders are selling and those of you who are smart enough to read between the lines know what to do.