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Trump Media & Technology Group Corp. engages in operating social media and in the technology business. Its brands include TRUTH Social, TMTG+, and TMTG News. It operates through the Media and Truth.Fi segments. The Media segment includes products and services such as advertisement through the Truth Social platform. The Truth.Fi segment relates to customized exchange-traded funds or exchange-traded products invested in America First principles, and bitcoin and similar cryptocurrencies or crypto-related securities. The company was founded on March 28, 2024 and is headquartered in Sarasota, FL.

Trump Media & Technology Group Corp.

DJT is drawing attention after falling to reported record lows, with traders pointing to concerns about Trump Medias losses, dilution, weak Truth Social engagement and Trumps declining approval ahead of the midterms. The discussion is overwhelmingly bearish, though some traders frame the drop as a buying opportunity.

QXO, Inc. is a publicly traded distributor of roofing, waterproofing and complementary building products in the United States. It plans to become tech-enabled in the building products distribution industry and generate outsized value for shareholders. The company was founded on October 3, 2002, and is headquartered in Greenwich, CT.

QXO Inc.

QXO is drawing attention for its prolonged selloff and repeated lows, amid analyst target cuts and concerns about weak roofing and housing demand, elevated rates, and the debt and dilution tied to its acquisition-led expansion. Traders are split between expecting further declines and viewing the depressed valuation as an opportunity if the roll-up strategy delivers integration and margin progress.

CoreWeave, Inc. engages in the powers of the creation and delivery of the intelligence that drives innovation. It offers a solution used by organizations of all sizes that require sophisticated AI computing, from the largest of enterprises to small, well-funded start-ups. The company was founded by Michael Intrator, Brian Venturo, Peter Salanki, and Brannin McBee on September 21, 2017 and is headquartered in Livingston, NJ.

CoreWeave Inc. - Ordinary Shares - Class A

CoreWeave Inc

Concerns about CoreWeaves debt burden, bond-market stress and ability to finance its AI data-center expansion dominate the discussion, while Goldman Sachs Buy upgrade has fueled hopes for a rebound. Traders remain divided: bulls call the selloff overdone and anticipate a squeeze, while bears say financing risks and weak price action outweigh the upgrade.

MARA Holdings, Inc. is a digital asset technology company, which engages in mining cryptocurrencies with a focus on the Bitcoin ecosystem. It also deals with owning and operating bitcoin mining facilities or data centers, selling proprietary software or technology to third parties operating in the Bitcoin ecosystem, offering advisory and consulting services to support Bitcoin mining ventures in domestic and international jurisdictions, and generating electricity from renewable energy resources or methane gas capture to power Bitcoin mining projects. The company was founded on February 23, 2010 and is headquartered in Hallandale Beach, FL.

MARA Holdings Inc.

Marathon Digital Holdings Inc

MARAs prolonged selloff and sharp underperformance despite Bitcoin holding near elevated levels dominate discussion, with traders blaming weak sentiment and the lack of signed AI/data-center tenant deals. Bearish frustration over management and the unproven pivot competes with dip-buying and speculation that a lease announcement or Bitcoin rebound could lift shares.

AXT, Inc. engages in the design, development, manufacture and distribution of compound and single element semiconductor substrates. It also sells specialty material substrates and raw materials used to make substrates and other related products. The company was founded by Morris S. Young and Davis Zhang in 1986 and is headquartered in Fremont, CA.

AXT Inc

AXTI is drawing attention for its sharp, volatile moves and its role as an indium phosphide substrate supplier for AI data-center optics. Bulls point to AI-driven demand and recent business momentum, while bears argue the shares are overvalued and flag China-related supply risks; the debate is amplified by heavy trading around earnings and technical levels.

Disc Medicine, Inc. is a clinical-stage biopharmaceutical company, which engages in the discovery, development, and commercialization of treatments for hematologic diseases. It assembles a portfolio of clinical and preclinical product candidates that aim to modify fundamental biological pathways associated with the formation and function of red blood cells, specifically heme biosynthesis and iron homeostasis. The company was founded in October 2017 and is headquartered in Watertown, MA.

Disc Medicine Inc

Disc Medicine shares are surging after bitopertin met all primary and secondary endpoints in the Phase 3 APOLLO trial for erythropoietic protoporphyria, addressing the FDAs earlier concerns about clinical benefit after a prior rejection. Traders are debating whether the move has room to extend, including speculation about short covering, versus profit-taking and resistance; FDA approval is still pending, and some raise concerns about dizziness reported in the trial.

Sunrun, Inc. engages in the design, development, installation, sale, ownership, and maintenance of residential solar energy systems. It sells solar service offerings and installs solar energy systems for homeowners. Customers can access its products through three channels: direct-to-consumer, solar partnerships, and strategic partnerships. The company was founded by Edward Harris Fenster, Robert Nat Kreamer, and Lynn Michelle Jurich in January 2007 and is headquartered in San Francisco, CA.

Sunrun Inc

Sunruns push to monetize its residential solar-and-battery network for distributed power and AI computing is a major topic, with traders debating the potential of its pilot and partnerships against the stocks persistent weakness. Bulls also point to heavily short positioning, while bears cite financing and interest-rate sensitivity and broader solar-sector pressure.

Annaly Capital Management, Inc. engages in the investment and financing of residential and commercial assets. It operates through the following segments: Agency, Residential Credit, Mortgage Servicing Rights (MSR), and Corporate and Other. The Agency segment invests in agency mortgage-backed securities. The Residential Credit segment is involved in non-agency residential mortgage assets within securitized products and whole loan markets. The MSR segment provides the right to service residential mortgage loans in exchange for a portion of the interest payments made on the loans. The company was founded by Michael A. J. Farrell and Wellington Jamie Denahan-Norris on November 25, 1996 and is headquartered in New York, NY.

Annaly Capital Management Inc

NLY is drawing attention after sliding to reported 52-week lows alongside other mortgage REITs, with traders tying the weakness to interest-rate and mortgage-bond repricing concerns. Some view the selloff as a chance to buy for the high dividend, while others worry that persistent rate pressure could weigh further on the shares and payout.

Coinbase Global, Inc. engages in the provision of a trusted platform that serves as a compliant on-ramp to the onchain economy and enables users to engage in a wide variety of activities with their crypto assets in both proprietary and third-party product experiences enabled by access to decentralized applications. It offers consumers primary financial account for the cryptoeconomy, institutions a full-service prime brokerage platform with access to deep pools of liquidity across the crypto marketplace, and developers a suite of products granting access to build onchain. The company was founded by Brian Armstrong and Fred Ernest Ehrsam in May 2012 and is headquartered in New York, NY.

Coinbase Global Inc - Ordinary Shares - Class A

Coinbase Global Inc

Bitcoins volatile swings and the rebound in crypto-linked stocks are driving attention to Coinbase, with traders frequently debating whether COIN is lagging the crypto market. Sentiment is split between optimism ahead of Q3 earnings and skepticism over the stocks sharp reversals and weak relative performance.

Amazon.com, Inc. is a multinational technology company, which engages in the provision of online retail shopping services. It operates through the following segments: North America, International, and Amazon Web Services (AWS). The North America segment offers retail sale of consumer products, including from sellers, advertising, and subscriptions services through North America-focused online and physical stores. The International segment focuses on retail sale of consumer products, including sellers, advertising, and subscription services through internationally focused online stores. The AWS segment is composed of global sales of computers, storage, databases, and other services for start-ups, enterprises, government agencies, and academic institutions. The company was founded by Jeffrey P. Bezos in July 1994 and is headquartered in Seattle, WA.

Amazon.com Inc.

Amazon.com Inc

Morgan Stanley naming Amazon a top pick, citing AWS growth and AI opportunities, is the main catalyst behind the sharp rally. Traders are broadly upbeat, while some question whether the upgrade-driven move will hold and remain cautious about capex and the upcoming earnings report.

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Equity

Deals for AI discovery platforms and differentiated experimental candidates for obesity and solid tumors dominated the week.


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Roche Holding AG is a research healthcare company. It operates through the Roche Pharmaceuticals and Diagnostics segments. The Roche Pharmaceutical division comprises the business segments, such as Roche Pharmaceuticals and Chuga. The Diagnostic division consists of the following four business areas: centralized and point of care solutions, molecular diagnostics, tissue diagnostics, and diabetes care. The company was founded by Fritz Hoffmann-La Roche on October 1, 1896 and is headquartered in Basel, Switzerland.

Roche Holding AG - ADR

Bearish Sentiment

<ul class="summary-bullets"><li><a class="mention" data-mention="$GILD" data-symbol-id="GILD" href="https://stocktwits.com/symbol/GILD" target="_blank">Gilead Sciences</a> partnered with Vir Biotechnology on Wednesday to discover and develop three drugs aimed at solid tumors.</li><li>AstraZeneca signed an up-to-$1.5 billion AI collaboration with insitro for MASH and cardiomyopathies.&nbsp;</li><li>Roche licensed Rona’s drug candidate, and Zealand Pharma teamed with Generate on AI-designed proteins for differentiated obesity approaches.</li></ul><p>Large pharmaceutical companies including Gilead Sciences, Roche and AstraZeneca spent this week securing access to discovery technologies and experimental candidates that address clear biological gaps, instead of large-scale acquisitions of rival firms or approved products.</p><p>Obesity and cancer remained the clear focal points, with several of the week’s biggest partnerships aimed at differentiated weight-loss mechanisms or new solid-tumor approaches.</p><h2 class="st-heading-2">Gilead Partners With Vir For New Cancer Drug Candidates</h2><p>Gilead Sciences (GILD) partnered with Vir Biotechnology (VIR) on Wednesday to discover and develop three drugs aimed at solid tumors. Vir will handle early discovery, design, and optimization using its AI-enabled protein engineering tools and PRO-XTEN masking technology. Gilead receives exclusive rights to nominate candidates and will lead subsequent development, manufacturing, and commercialization.</p><p>Vir is eligible for $90 million upfront—$65 million in cash plus a $25 million equity investment at a premium—plus up to $45 million in near-term preclinical milestones and as much as $1.74 billion in later development, regulatory, and commercial payments, along with tiered royalties. The agreement marks Vir’s second major partnership around its masking platform this year after a previous deal with Astellas and adds to Gilead’s attempts to advance its cancer offerings besides its blockbuster drug Trodelvy.</p><h2 class="st-heading-2">AstraZeneca Taps Insitro’s AI Platform</h2><p>AstraZeneca (AZN) signed a worldwide exclusive research collaboration with privately held AI therapeutics company insitro focused on metabolic dysfunction-associated steatohepatitis (MASH) and cardiomyopathies. Insitro will apply its Virtual Human platform, which combines human and cellular data with AI, to identify causal disease biology and advance AstraZeneca-nominated targets through discovery to the development-candidate stage.</p><p>AstraZeneca will lead clinical development, regulatory work, and commercialization. Insitro will receive $40 million upfront and is eligible for up to approximately $1.46 billion in discovery, development, and commercial milestones, plus single-digit royalties on potential sales.</p><h2 class="st-heading-2">Roche, Zealand Pharma Add Differentiated Obesity Approaches</h2><p>Roche secured exclusive worldwide rights to Rona Therapeutics’ investigational drug candidate which targets a protein predominantly expressed in fat tissues. The drug candidate is designed to selectively reduce visceral and ectopic fat while preserving lean mass—an attractive complement to currently popular obesity drug classes like GLP-1. Rona is eligible for up to $100 million in upfront and near-term payments, up to $1.06 billion in additional milestones, and tiered royalties.</p><p>Separately, Zealand Pharma entered a collaboration with Generate Biomedicines (GENB) to design multispecific protein therapeutics for obesity and other metabolic diseases using Generate’s generative AI platform. Generate will lead research through lead-candidate selection for two initial programs, with an option for a third; Zealand will handle clinical development, regulatory submissions, and commercialization. Generate receives $30 million upfront, up to $35 million in early preclinical milestones, and nearly $1.2 billion in total potential milestones, plus royalties.</p><h2 class="st-heading-2">Pfizer, Galderma Make Platform And Commercial Moves</h2><p>Pfizer (PFE) partnered with privately-held Enodia Therapeutics on a research collaboration and license for compounds intended to block disease-driving proteins at the point of synthesis. The potential value exceeds $500 million, including an upfront payment, milestones, and royalties; Enodia will run discovery against multiple targets while Pfizer takes over later development and commercialization.</p><h2 class="st-heading-2">How Did Retail Traders React?</h2><p>On Stocktwits, retail sentiment around SPDR S&amp;P Biotech ETF (XBI) fell from bullish to neutral territory over the past 24 hours, while message volume stayed at normal levels.</p><p><a href="https://stocktwits.com/symbol/XBI">XBI</a> has fallen 4% over the past week as part of a broader biotech pullback that began after its mid-August peak near $170, but it is up 22.5% year-to-date.&nbsp;</p><p>Read More: <a href="https://stocktwits.com/news-articles/markets/equity/novartis-discontinues-mid-stage-lupus-trial-in-latest-pipeline-setback/cZxKiBhRBtc">Novartis Discontinues Mid-Stage Lupus Trial In Latest Pipeline Setback</a></p><p>For updates and corrections, email newsroom[at]stocktwits[dot]com.</p>

Digital background depicting innovative technologies in medicine systems. Source: Getty Images

Deals for AI discovery platforms and differentiated experimental candidates for obesity and solid tumors dominated the week.

AstraZeneca PLC

Generate Biomedicines Inc

Gilead Sciences, Inc.

Pfizer Inc

Roche Holdings AG ADR

Vir Biotechnology Inc

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