AVXL Anavex Life Sciences Corp

$AVXL After a quick chat with management, I feel much more confident going forward with this investment. You can sense how deliberately Terrie wants to run the company. The narrowed pipeline allows the company to retain fiscal responsibility while conducting hand-in-hand relationships with regulators (namely the FDA). With Dr. Missling gone and the board having been 'revitalized', Anavex's leadership has a real opportunity to leverage industry experts and make this thing happen in a wholly collaborative ecosystem/consortium. Expect updates as they come. Otherwise, sit back and let's see how the new team gets to business - the cogs are already in motion.

$AVXL Step back and think about it for a moment ... the ineffective management has been removed. The ineffective attempt by PVG (and a lame one at that) has been eliminated. As someone mentioned below, the 'adults' are now running the show. Seriously, TK and the board stepped in, they are going though a disciplined and methodical process to rebuild trust with the shareholder community and the regulatory agencies. That's not an overnight thing and yet they are making rapid progress. TK promised updates between now and November as meaningful and significant events unfold. At this point a modicum of patience is certainly warranted.

$AVXL I still expect my AVXL investment to pay off. Strange as it seams, I can’t think of a stock with better price appreciation potential than AVXL. With AVXL’s legacy staff now out of the picture, and all intellectual property still fully under the company’s control, and no competitors with a proven technological advantage, I think success is possible. Let’s get some well regarded hedge funds to invest in Anavex, and then move ahead under their watchful eyes.

$AVXL I talked to Cliff today, he did not say this directly, but Rett sounds like is first. Meeting with FDA very soon for AD trial design, said don't put faith in anything Missling said so at this point could be 1,500 patients or could be something totally different. What got me excited about Rett is that sounds like it will be US sites only, my impression so don't put much into it is that all the noise came from sites that were having non-experienced people filling out the questionnaires. I imagine when Terrie removed that noise she got a clear picture. For Rett: This is my thoughts, that Rett community is a super tight knit group. I think enrollment this time will be different. I think Mothers will be clamoring to the sites and I half wonder if it could be enrolled in a few months, once it is announced I am thinking there will be a waiting list to get into the trial, they know all the miraculous stories by now. Its not about getting on drug, for them it will be about getting the drug to market. If that is the case, it could actually be quite quick. the trial will only be 12 weeks, you might have the whole thing done in a year if you had 20-25 very experienced centers. For Fragile X nothing new they looked at mode of action and they think it is a very strong target. No idea if we can go right into a p2/3 but if Anavex can, Fragile X has a similar caregiver group to Rett. They might be able to use the same strategy to quickly bang out that trial as well. If Rett is worth a billion, Fragile X is worth 10 billion. Well I am the most excited I have been since EMA smackdown day about Anavex.

$AVXL I did a deep dive into Anavex’s steep price decline, this is what I found. This sudden drop is tied to official events, most notably: 1.) The recent Wave of Class Action Lawsuits: On 9/30 and 10/1, multiple prominent law firms filed class action lawsuits against Anavex. 2.) These lawsuits are based on the company's own prior SEC filings. They point directly to Anavex’s admission of "material weaknesses in internal control over financial reporting” and the fallout surrounding the termination of Missling for cause earlier this year. 3.) The termination of C.M. on April 30th was for conduct "inconsistent with Company Policy," a development the lawsuits claim was hidden until subsequent delayed regulatory filings forced the disclosure, harming shareholders. 4.) Seizing on these lawsuits, off-exchange short selling for Anavex has turned highly aggressive — all thanks to the misdeeds of Christoper Missling. I believe in the science, I am long Anavex, and I ain’t selling one share!

$AVXL I keep thinking about Terrie's comment on the call where they actually talked and how she said she is even more impressed with the drug with the work she has done after becoming president.

$AVXL For those concerned that the new board is "refusing to communicate," understanding Delaware corporate law and SEC filing mechanics explains why no public statement has been made yet. Post-proxy boards follow a standard 2-meeting playbook (Harvard Law School Forum on Corp. Governance and NACD guidelines): Meeting 1 (Days 0-2): Procedural. Certified election count & signing continuity (8-K Sept 28). 10-Day Gate: Clear diligence & get CIK codes to file Form 3 by statutory deadline. Senderowicz & Patel filed Oct 5 on schedule. Meeting 2 (Days 5-10): Substantive session to: • Reconstitute Audit/Comp committees (Nasdaq 5605). • Resolve CEO mandate (DGCL § 142): decide interim elevation vs. external search. • Align on 10-K audit for FY ended Sept 30. Management cannot front-run a new board before this wraps. SEC rules require Form 8-K within 4 business days of board action. The stock price reflects a temporary transition window, but governance moves on statutory calendars, not sentiment.

$AVXL FYI, all Alz stocks have taken A beating over the past month notably avxl, axsm and anvs. Nothing has changed w the science or trial data or the plan moving forward. In fact the next 3 months have multiple catalysts inc potentially an adaptive, accelerated approval trial design for Alz. That trial (which would include AbClear3 for accelerated) at this stage, added 15-20b to each of the MAB companies. It’s a game changer if awarded. Be certain, that’s the data driven direction Anavex will be pursuing. We will know soon enough. Team is collaborating w regulators to deliver on 3 new trials. Amazing what can be accomplished and time saved over the lifecycle when you engage upfront with those who approve. Ask for forgiveness later doesn’t work in this space. GLTA

$AVXL In biotech the price always has to get ridiculously stupid, then you say well this is rock bottom, then go through that exercise about 3-4 more times then you hit rock bottom. But seems like 10 million for blarcamisine less cash is a pretty good deal.

$AVXL Once Blarcamesine sees the light of day, the approvals will fall via off label authorizations. With little to no down side to taking this medication, companionate use and right to try will certainly be popular options for the sick. Dosage will be the only challenge. Good luck fell “bag holders” Possibly.. soon to be money bag holders. I’m about to double down… again. Fair skies coming into Barcelona!

$AVXL I bought another 10k shares, up to 150k now. Be greedy when everyone is fearful. Only has to get to $2.60 to double your money. 😎

$AVXL I bought 4K more shares at $2.25, a little early admittedly, but riding this out. I remember buying around 8k shares around the same price way back when and it was the Best Buy ever, although I didn’t ever sell and capitalize on them. This will turn around, just not fast. Hope the longs here are all doing well!

$AVXL FOR LONG TIME SHAREHOLDERS LIKE MYSELF (10 PLUS YEARS) ONE MUST COME TO THE FINAL CONCLUSION THAT OUR INVESTMENT IS GONE AND CANNOT POSSIBLY RECOVER. THERE IS NO DOUBT A REVERSE SPLIT WILL BE FORTHCOMING IN THE NEAR FUTURE WHICH WILL MAKE SAID RECOVERY VIRTUALLY IMPOSSIBLE. SHOULD AVXL ACTUALLY ONE DAY BY MIRACLE ACHIEVE AN FDA APPROVED DRUG THE ONLY WINNERS WILL BE THE NEW INVESTORS IN THE STOCK ONLY. PERSONALLY, I HAVE RECOVERED MY LOSSES IN AVXL WITH OTHER STOCK INVESTMENTS. MY SORROW IS FOR THE PATIENTS LIKE MY LATE MOTHER THAT 2 73 COULD HAVE POSSIBLY HELPED AND LESSEN THEIR SUFFERING. SADLY, THE DRUG WAS IN THE HANDS OF INCOMPETANTS THAT LED TO ITS DENIAL. REMEMBER, THE HINTS WERE THERE WITH THE RETT TRIAL FAILURE.

$AVXL I own a ton of this stock, but with the PR yesterday and this artificial pullback it's very tempting to pull out the checkbook and add some more.

$AVXL Top line results of the Blarcamesine Phase 2b/3 Alzheimers trial were first presented on December 1, 2022 at CTAD. Dr. Stepen MacFarlane was the presenter. On December 5, 2022 Anavex hosted a conference call between CEO Christopher Missling, Dr. Timo Grimmer, Dr. George Perry, and investors. Doctors Grimmer and Perry didn't think Blarcamesine could be approved based on the trial's results. However, Dr. Grimmer did mention that he thought a pathway for conditional approval was possible, w/the requirement that Anavex initiate a confirmatory trial. Both doctors said that Blarcamesine would eventually be approved for the treatment of Alzheimers Disease. Their confidence in the drug should give investors confidence.

$AVXL The rational ones all left a long time ago and as I am doing only check in from time to time to see if there is still a pulse here. Barely. Anavex will be fine, folks. Maybe not in the timeline some hoped for but the drug most likely will work in the next trial, the issue wasn't data fabrication but rather too small of a trial because our CEO was hoping the EMA or FDA would buy into "precision medicine" allowing him to save time and money with a back-door path to approval. Our new team is doing it the traditional way which takes time and money. Fortunately we have money so dilution won't be too extreme. We also have a drug compound that I believe for a P2 is still very desirable so I'd expect a bidding war for a partnership. For the price to be trading .25 above cash is interesting. Either the data is completely made-up or there is an arbitrage opportunity about to take place with the options market.

$AVXL It’s been a very busy time. I guess I’m lucky to have a medical problem that was corrected by heart catheter. AD? They all chase. But we have Blarcamesine. All around us, fuckery. But we still have it. I still have a significant stake in this company. I’m about to get a very nice bonus… which will go to more shares. My average should be around $2.50 I also think that Blarcamesine has other benefits not yet discovered. Just like GLP1 drugs. I’m very optimistic.

$AVXL One task cleared. Seems like she's on task and kicking ass so far. These no-nonsense bits will keep coming, short and sweet. FDA suits probably glad it's not Chris. 🤷🏻‍♂️

$AVXL - I keep reading the same type of posts, over and over again, asking, then demanding answers...Answers to what? The company just went through major restructuring, and a not so hostile attempt to take control by a fly by night, clueless hedge fund, that more than likely had a strong backing with the previous CEO. Oh, and let's not forget the endless law firms lined up to bleed us dry. Nobody likes the ridiculously low stock price "I know I don't", but there's nothing to do than ride this out, or sell. And lastly, what would you like the new CEO to say, that wasn't just said that long ago. We had 10-years of empty promises, let's give this a year or two and see if the new administration pays off. I'm betting it will "hoping" it will. Adios Muchachos!!! Semi..Kinda Sort Of...

$AVXL Okay Terri, now is the time to do something Missling always missed: "Execute the Game Plan!" Oh, and tell investors exactly what that Game Plan actually is and not in Missling obfuscation speak.